Experiences with antidepressant medication

The effectiveness and adverse effects of antidepressants have been the subject of a great deal of research and competing claims, including about whether antidepressants address the underlying causes of depression.
Most people we talked with had some experience with antidepressants, usually in combination with other forms of treatment, and held diverse views about them. Many people had experiences with antidepressants; however people’s description of their experiences ranged from positive to negative. While some people described them as a ‘saviour’, others who had positive experiences still held ambivalent feelings about them. Several people described the fraught journey of trying to find a medication that would work for them, with side-effects they could tolerate. For others, the ‘right’ medication had eluded them completely.
Those who were opposed to antidepressants were concerned about becoming addicted or were reluctant to take medication in general. The majority of people were taking medication at the time of interview and this had been prescribed by GPs or psychiatrists. Most people described significant side effects; however, they chose to keep taking antidepressants as they claimed that, for them, benefits outweighed the side effects. A few people told us that they had experienced less significant side effects.

Finding the ‘right’ medication – benefits

The benefits described by people taking antidepressant ranged from insignificant to helpful. People talked about feeling ‘levelled right out’, ‘calm’, and ‘normal again’. Dani said that antidepressants ‘helped to clear my head and put me in a position where I [could] take care of myself and do the things I need to do’. The majority of people reported needing to keep taking antidepressants for an extended time to experience any benefits, while others described rapid positive change soon after starting on them. Often family members were said to be the first to notice a positive change in the person.

John talked about the swift transformation he experienced upon starting antidepressants.

Age at interview 40

Gender Male

Age at diagnosis 37

View profile

The importance of finding the ‘right’ antidepressant was frequently mentioned and most people tried a few before they found one that worked for them. Some believed they would be on antidepressants for life. The difference between a medication that did not work and one that did was described by one woman as the difference between feeling ‘very zombie-like and more depressed’ and feeling ‘just normal and just calm’.
Comments were made about ‘older style’ and ‘newer’ antidepressants and the different adverse effects of each. Being able to discuss medication and its effects, and making shared decisions with their treating doctor was always appreciated. Some suggested people should be closely monitored by health professionals while on antidepressants.

Gabrielle said she tried different antidepressants and sleeping tablets until she found a…

Age at interview 42

Gender Female

Age at diagnosis 23

View profile

Ivan was guided by a trusted GP through a number of antidepressants until he found the right one…

Age at interview 58

Gender Male

Age at diagnosis 52

View profile

A few people believed that their depression was caused by a chemical imbalance (see ‘Views about causes of depression’). Some holding this view said that they thought antidepressants were the most effective therapy for them and they tended to stay on antidepressants even after they felt better. In these instances, staying on antidepressants after an improvement in mental health was advised by their doctors.

Ruth talked about being happy to continue taking antidepressants as they made her feel herself.

Age at interview 49

Gender Female

Age at diagnosis 31

View profile

Some men were reluctant to start taking antidepressants as they were concerned that antidepressants would ‘control’ them. One man changed his mind after he felt suicidal and was concerned that he might self-harm. A few people who tried to adjust their dosage without medical supervision described experiencing negative consequences. The importance of taking antidepressants for a sufficiently long period was emphasised by some people, who explained that it took time for the positive effects to outweigh the negative effects. A few said being ‘regular as clockwork’ in taking medication was very important.

Paul discussed the importance of staying on antidepressants and coping with the side effects long…

Age at interview 39

Gender Male

Age at diagnosis 29

View profile

Finding the ‘right’ medication – side effects and mixed effects of antidepressants

People’s experiences with the severity of side effects also varied, from barely noticeable to severe. Side effects mentioned included’ muscular pain; feeling ‘light in the head’; ‘spaced out’; short term memory loss; feeling ‘low’; ‘numb’; feeling indifferent to good things happening in peoples’ lives; losing interest in sex; not ‘feeling themselves’; feeling ‘in another world and another time’; difficulty concentrating; and dizziness. Emma said her thoughts were ‘a bit all over the shop’.
A few people were introduced to antidepressants following traumatic events in their lives. As a result of these events, some people experienced prolonged distress and resorted to taking antidepressants for a long time; others took them for a while then stopped.

Following his doctors advice, Phil originally took antidepressants to help him through serious…

Age at interview 52

Gender Male

Age at diagnosis 37

View profile

Jules described progressing from starting antidepressants almost ‘by accident’ following a tragic life event, to using them long-term, despite not finding one that was effective.

Jules was given antidepressants by her GP without asking for them following her husbands death…

Age at interview 61

Gender Female

Age at diagnosis 55

View profile

Shaz, who had a long history of depression persisted with taking different antidepressants over the years together with a range of other medications for her mental health including antipsychotic, anti-anxiety and mood stabilising medications, guided by her psychiatrist. She described experiencing side effects and no apparent positive outcomes.

Shaz described different medications she had tried for her mental health, but didnt know much…

Age at interview 46

Gender Female

Age at diagnosis 19

View profile

Some people hid the fact they were on medication after being judged as ‘weak’ or not ‘in control’ for taking them. Jane talked about not disclosing that she was taking antidepressants, even though she thought they helped.

Jane was happy to answer direct questions about her perinatal depression and antidepressants but at the same time did not tell people voluntarily.

Age at interview 39

Gender Female

Age at diagnosis 29

View profile

Reasons for not taking antidepressants and being ambivalent about them

Some people remained reluctant to take antidepressants even after they had tried them, regardless of the potential benefits that their doctors had explained to them. Reasons ranged from observing effects of medication on their relatives, wanting to feel ‘in control’ of themselves, or having good experiences with talking treatments (see ‘Talking treatments’).

Millaa outlined his reservations about taking antidepressants.

Age at interview 20

Gender Male

Age at diagnosis 15

View profile

Ron thought antidepressants were mainly helpful at the beginning of recovery process.

Age at interview 62

Gender Male

Age at diagnosis 27

View profile

Susan felt ambivalent about antidepressants, but was aware of their benefits for her and was…

Age at interview 61

Gender Female

View profile

Stopping taking antidepressants

There was a large variation in the length of time people kept taking antidepressants; from a short trial to being on them ‘for life’. Some people reported stopping abruptly which was sometimes associated with bad side effects. Others talked about the need to reduce the dose gradually. Safra was convinced she would be on medication for life and said stopping made her go back to a ‘deep depression’.

Safras view was that she would remain on antidepressants for life, as medication helped her…

Age at interview 56

Gender Female

Age at diagnosis 52

View profile

Even when stopping was gradual and advised and supervised by a medical professional, some people experienced significant side effects which took them some time to get over.

Emma talked about significant negative effects of the antidepressant she was taking, once she…

Age at interview 33

Gender Female

Age at diagnosis 32

View profile

Talking therapies

In Australia, a variety of therapists provide a range of counselling and talking therapies. These include Cognitive Behavioural Therapy (CBT), psychodynamic therapy, humanistic therapy, interpersonal...