Tony – Interview 36
Tony took part in a double-blind, placebo-controlled trial of Viagra (sildenafil) for erectile dysfunction following a prostate operation. He was in the placebo arm but was given Viagra after the trial ended. (Husband of Pam, Interview 21).
Tony was diagnosed with benign prostate hypertrophy – enlarged prostate – approximately 12 years ago. He was treated by a surgical procedure called TURP, transurethral resection of the prostate. Possibly as a side effect of the procedure, Tony later developed erectile dysfunction. He was referred back to the urologist who had treated him before. The urologist told him there was a drug company-funded trial of Viagra (sildenafil), which at the time was a new drug. The trial would be comparing a placebo with the drug, and neither the doctor nor Tony would know whether he was taking the placebo or Viagra (a double-blind, placebo-controlled trial).
Tony’s view is that trials are essential for medical knowledge to progress. He knows he has benefited from drugs that have been trialled on other people in the past, so he feels there is no reason why he should not also take part in trials to benefit future generations. It was explained to him that there were some potential serious side effects, but he was willing to take part anyway.
During the trial, his erectile dysfunction did not improve, and Tony guessed he must be on the placebo. It never occurred him to withdraw from the trial, however, because once he had started he felt there was a commitment to see it through to the end. As part of the trial he had to complete regular questionnaires about both physical symptoms and his psychological well-being.
At the end of the trial, everyone who had been on the placebo was offered an opportunity to take the real drug, and immediately he noticed an improvement in his symptoms. The research assistant on the trial told him that once it was approved for NHS use he would probably be eligible to have it prescribed on the NHS because of his prostate condition.
Tony would like to see more research carried out generally into prostate cancer, which he sees as a neglected area. It is likely he will have to have another TURP operation, which he is not looking forward to as it is an unpleasant procedure. Finding alternatives to the surgery would be a major step forward.